Arterial thrombosis (acute coronary syndrome or stroke) in Glanzmann Thrombasthenia (GT) patients poses a major clinical challenge. These rare but serious events are extremely difficult to manage, given the inherent bleeding risk in GT and the absence of evidence-based therapeutic guidelines. Available data are limited to a few case reports, and the heterogeneity of hemostatic strategies highlights the urgent need for standardized recommendations.
To address this gap, the GlanzArter project aims to retrospectively analyze an international cohort of adult GT patients who have experienced an arterial thrombotic event, including acute coronary syndrome or stroke. The study will describe patients' demographic and biological characteristics, cardiovascular risk factors, diagnostic procedures, hemostatic and interventional management, and outcomes, including bleeding complications. This is an official collaborative project of the ISTH SSC Subcommittee on Platelet Physiology.
The ultimate goal is to identify critical patterns and management strategies that may inform future guidelines for the care of GT patients facing arterial thrombotic events.
We are conducting a retrospective data collection through two structured CRFs (one for acute coronary syndrome, one for stroke). These have been developed by an expert panel in hemostasis, cardiology, and neurology. All data will be pseudonymized and stored in a secured database hosted by Marseille University Hospital (France).
We are now inviting all centers involved in the care of GT patients worldwide to contribute by reporting any case of stroke, transient ischemic attack, acute coronary syndrome, or unstable angina in adult GT patients. Even a single case per center is highly valuable due to the rarity of the condition.
Your participation is essential to help improve the care of these vulnerable patients.
To receive the protocol and CRFs, as well as further information please contact Prof. Paul Saultier (paul.saultier@ap-hm.fr). (See full project description under "Current Projects" on the ISTH website.)