SSC Subcommittee on Platelet Physiology

This subcommittee is focused on all aspects of the biology and function of platelets and their role in thrombosis, hemostasis and normal physiology. The SSC incorporates hematologists, cardiologists, laboratory scientists, health professionals and academics.

If you are interested in the subcommittee and want to follow its activity, please click "join group" above to sign up as a member (follower). 

Mandate

• To address issues of practical importance to the research community in the field
• To evaluate existing data, determine issues for which data is missing or deficient, identify areas of controversy or clinical need and discuss methodological approaches to answer the questions raised.
• To create international collaborations for the purpose of planning and executing projects related to the defined needs in the field.
• To suggest or organize collaborative studies as a result of these activities
• To generate, publish and distribute reports, recommendations, position statements and other documents concerning the above.
• To develop laboratory standards, methods and nomenclature if appropriate.

Role

The following are the ongoing activities and responsibilities of the Subcommittee.

• The subcommittee interacts with the ISTH community to identify topics requiring standardization.
• The subcommittee promotes forums and blog to discuss controversial issues in Platelet Physiology.
• The subcommittee promotes international surveys on current practice.
• The subcommittee promotes international collaborative standardization studies.
• The subcommittee appoints experts into specific project groups.

If you are a member of the Society and would like to know how to participate in the work of this group, please join the group to receive updates on activity or submit an Expression of Interest Form to the Chairman or any of the Co-Chairmen. We would be pleased to learn of your interest.

Leadership

• Chair - Sofia Ramstrom
• Co-chair - Emma Josefsson
• Co-chair - Georges Jourdi
• Co-chair - Alexandre Kauskot
• Co-chair - Eleonora Petito
• Co-chair - Rutvi Gautam Dave
• Co-chair - Scott Cameron
• Co-chair - Pierre Fontana
• Co-chair - Dianne van der Wal

Current Projects

• International multicenter assessment of methods to detect platelet dense granule deficiencies project began 2022, projected end TBD
• Standardization of flow cytometric method to study reticulated platelets and comparison of automated clinical analyzers, project began 2025, projected end 2027
• Survey on the prevalence of gastrointestinal bleeding in Glanzmann Thrombasthenia patients, project began 2024, projected end 2026
• Standardization of Washed Platelet Preparation Methods for Proteomic Analysis (The SWAP study), project began: 2023, projected end TBD
• Consensus protocol for quantification/detection of surface platelet glycans by using lectins project began: 2023
• International multi-center validation of flow cytometry methods for the detection of Tissue-factor positive platelets project began: 2023, projected end TBD
• Development of Consensus on Standardized Nomenclature for PT-VWD
  project began: 2021, projected end 2023
• Platelet Function Testing in Patients with Low Platelet Counts
  project began: 2021, projected end: 2023 (cytometry), 2024 (aggregometry)
• Standardizing Platelet Transcriptomics for Discovery, Diagnostics, and Therapeutics in the Thrombosis and Haemostasis Community: The STRIDE Study
  project began: 2019, projected end 2023
• Biomarker of in vivo platelet activation - a systematic review and meta-analysis
  project began: 2019, projected end 2023
• Immune Thrombocytopenia and Obstetric Neuraxial Anesthesia at Low Platelet Counts – An International Registry
  project began: 2019, projected end 2029; See Registry Here
• Evaluation of the ISTH Bleeding Assessment Tool (BAT) for the assessment of inherited platelet function disorders: individual-level meta-analysis
  project began: 2020, projected end 2023

Official Communications

• Minutes
• Bibliography
• Publication Guidelines