This subcommittee is focused on all aspects of the biology and function of platelets and their role in thrombosis, hemostasis and normal physiology. The SSC incorporates hematologists, cardiologists, laboratory scientists, health professionals and academics.
If you are interested in the subcommittee and want to follow its activity, please click "join group" above to sign up as a member (follower).
Mandate
- To address critical issues in platelet biology and pharmacotherapy, encompassing their roles in thrombosis, haemostasis, and related disorders.
- To standardize and provide consensus protocols for platelet function tests used for research and diagnostic purposes of bleeding and pro-thrombotic patients, specifically: platelet activating agents, platelet sample preparations, settings of general equipment such as flow cytometers
Role
The following are the ongoing activities and responsibilities of the Subcommittee.
- The subcommittee interacts with the ISTH community to identify topics requiring standardization.
- The subcommittee promotes forums and blog to discuss controversial issues in Platelet Physiology.
- The subcommittee promotes international surveys on current practice.
- The subcommittee promotes international collaborative standardization studies.
- The subcommittee appoints experts into specific project groups.
If you are a member of the Society and would like to know how to participate in the work of this group, please join the group to receive updates on activity, contact the PI of the project you are interested in, or submit an Expression of Interest Form to the Chairman or any of the Co-Chairmen. We would be pleased to learn of your interest.
Leadership
- Chair - Sofia Ramstrom
- Co-chair - Yana Roka Moiia
- Co-chair - Emma Josefsson
- Co-chair - Georges Jourdi
- Co-chair - Alexandre Kauskot
- Co-chair - Eleonora Petito
- Co-chair - Rutvi Gautam Dave
- Co-chair - Scott Cameron
- Co-chair - Pierre Fontana
Current Projects
- International multicenter assessment of methods to detect platelet dense granule deficiencies project began 2022, projected end TBD
- How do soluble platelet-derived proteins relate to platelet reactivity in cardiovascular patients?, project began 2024, projected end 2027
- Role of Antiplatelet Monitoring in neuro-intervention: Literature Review and International survey, project began 2025, projected end 2027
- Recommendations for the standardization of platelet-leukocyte aggregates measurement by flow cytometry, project began 2025, projected end 2027
- Glanzmann thrombasthenia and arterial thrombosis (GlanzArter) project began 2025, projected end 2026
- Comparison of PAR-activating peptides with different C-terminal endings project began 2025, projected end 2026
- Update of the recommendations for the standardization of light transmission aggregometry of the ISTH SSC on platelet physiology, project began 2024, projected end TBD
- Standardization of flow cytometric method to study reticulated platelets and comparison of automated clinical analyzers, project began 2025, projected end 2027
- Survey on the prevalence of gastrointestinal bleeding in Glanzmann Thrombasthenia patients, project began 2024, projected end 2026
- Standardization of Washed Platelet Preparation Methods for Proteomic Analysis (The SWAP study), project began: 2023, projected end TBD
- International multi-center validation of flow cytometry methods for the detection of Tissue-factor positive platelets project began: 2023, projected end TBD
- Platelet Function Testing in Patients with Low Platelet Counts
project began: 2021, projected end: 2023 (cytometry), 2025 (aggregometry)\
- Immune Thrombocytopenia and Obstetric Neuraxial Anesthesia at Low Platelet Counts – An International Registry
project began: 2019, projected end 2029; See Registry Here
- Evaluation of the ISTH Bleeding Assessment Tool (BAT) for the assessment of inherited platelet function disorders: individual-level meta-analysis
project began: 2020, projected end 2023
Official Communications