The activities of this Subcommittee are focused on immune disorders of platelets including fetal/neonatal alloimmune thrombocytopenia, primary immune thrombocytopenia (ITP), drug-induced thrombocytopenia and heparin-induced thrombocytopenia. The main topics relate to the development and evaluation of biological assays for allo, auto, or drug-dependent antiplatelet antibodies, and the standardization of clinical disease criteria. This Subcommittee includes hematologists, biologists, laboratory scientists, and all practitioners working in the field of platelet immunology.
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Mandate
- To develop international laboratory standards, methods, and nomenclatures if appropriate.
- To address issues of practical importance to the research community in the field of platelet immunology.
- To evaluate existing data, determine issues for which data are missing or deficient, identify areas of controversy or pressing clinical need and discuss methodological approaches to answer questions raised.
- To create international collaborations for the purpose of planning and executing projects related to the defined needs in the field.
- To suggest and organize collaborative studies as a result of these activities.
- To generate, publish and distribute reports, recommendations and other documents concerning the above.
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Leadership
- Chair - Ishac Nazy
- Co-chair - James Michael
- Co-chair - Marie Hollenhorst
- Co-chair - Alessandro Aliotta
- Co-chair - Hanny Al-Samkari
- Co-chair - Dorothée Faille
- Co-chair - Karina Althaus
- Co-chair - Shiying Silvia Zheng
- Co-chair - Mirjana Mitrovic
Projects
- Standardization of methods to detect antibody-induced procoagulant platelets in heparin-induced thrombocytopenia project began: 2023, projected end: 2024
- Standardization of platelet antibody testing for ITP (excluding drug-induced ITP); project began: 2025, projected end: TBD
- Standardization of flow cytometric method to study reticulated platelets and comparison of automated clinical analyzers, project began 2025, projected end 2027
- Platelet Function Testing in patients with Low Platelet Counts project began: 2021, projected end 2024
- Biobanking Rare Platelet Antibodies project began: 2024, projected end 2027
- Characteristics of cyclic thrombocytopenia – an international registry project began: 2022, projected end 2033 LINK TO SURVEY
- Consensus paper on HIT management project began: 2023, projected end 2024
- Survey and Consensus paper of the functional HIT tests project began: 2023, projected end 2024 LINK TO SURVEY
- Immune Thrombocytopenia and Obstetric Neuraxial Anesthesia at Low Platelet Counts – An International Registry
project began: 2020, projected end 2030
Official Communications