This SSC subcommittee focuses on the function, clinical and laboratory aspects of the physiological anticoagulants and inherited thrombophilias, including but not restricted to, Antithrombin, Protein C, Protein S and Activated Protein C resistance (with or without Factor V Leiden), F2 G20210A and Prothrombin mutations resulting in Antithrombin resistance, as well as tissue factor pathway inhibitor (TFPI), heparin like substance and thrombomodulin.
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Mandate
- To address issues of practical importance to the research community in the field.
- To evaluate existing data, determine issues for which data is missing or deficient, identify areas of controversy or pressing clinical need, and discuss methodologic approaches to answer questions raised.
- To create international collaborations to plan and execute projects related to the defined needs in the field.
- To suggest or organize collaborative studies as a result of these activities.
- To generate, publish, and distribute reports, recommendations, and other documents concerning the above.
- To help standardize laboratory methods, and nomenclature if appropriate.
- To help develop and calibrate laboratory standards.
- Promote the training of professionals in the field.
- Encourage the integration of young trainees into the field.
- Facilitate interaction with patient associations.
Leadership
- Chair - Christelle Orlando
- Co-chair - Susan Louw
- Co-chair - Javier Corral
- Co-Chair - Christine Van Laer
- Co-Chair - Rinku Majumder
- Co-chair - Vera Ignjatovic
- Co-Chair - Kataryzna Mayger
- Co-chair - Paolo Simioni
- Co-chair - Beverley Hunt
Projects
Official Communications
Relevant Publications
- The use of direct oral anticoagulants in the secondary prevention of venous thromboembolism in patients with severe thrombophilia: communication from the ISTH SSC Subcommittee on Physiological Anticoagulants and Thrombophilia Kovac M, Ignjatovic V, Orlando C, Bereczky Z, Hunt BJ. The use of direct oral anticoagulants in the secondary prevention of venous thromboembolism in patients with severe thrombophilia: communication from the ISTH SSC Subcommittee on Physiological Anticoagulants and Thrombophilia. J Thromb Haemost. 2024 Nov;22(11):3322-3329. doi: 10.1016/j.jtha.2024.08.006
- Should we consider gene therapy in severe inherited thrombophilia? Communication from the ISTH SSC Subcommittee on Physiological Anticoagulants and Thrombophilia Hunt BJ, Corral J, Simioni P. Should we consider gene therapy in severe inherited thrombophilia? Communication from the ISTH SSC Subcommittee on Physiological Anticoagulants and Thrombophilia. J Thromb Haemost. 2023 Sep;21(9):2620-2622. doi: 10.1016/j.jtha.2023.06.032
- Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communication from the SSC of the ISTH.
Minford A, Brandao LR, Othman M, Male C, Abdul-Kadir R, Monagle P, Mumford AD, Adcock D, Dahlback B, Miljic P, DeSancho MT, Teruya J. J Thromb Haemost. 2022 https://doi.org/10.1111/jth.15732
- Recommendations for clinical laboratory testing for protein S deficiency: Communication from the SSC committee plasma coagulation inhibitors of the ISTH.
Marlar RA, Gausman JN, Tsuda H, Rollins-Raval MA, Brinkman HJM.J Thromb Haemost. 2021 Jan;19(1):68-74. doi: 10.1111/jth.15109.PMID: 33405382
- Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH.
Brinkman HJM, Ahnström J, Castoldi E, Dahlbäck B, Marlar RA.J Thromb Haemost. 2021 Jan;19(1):281-286. doi: 10.1111/jth.15108.PMID: 33405384
- Recommendations for clinical laboratory testing for protein C deficiency, for the subcommittee on plasma coagulation inhibitors of the ISTH.
Cooper PC, Pavlova A, Moore GW, Hickey KP, Marlar RA.J Thromb Haemost. 2020 Feb;18(2):271-277. doi: 10.1111/jth.14667.PMID: 31999059
- Recommendations for clinical laboratory testing for antithrombin deficiency; Communication from the SSC of the ISTH
Van Cott, EM, Orlando, C, Moore, GW, Cooper, PC, Meijer, P, Marlar, R; for the subcommittee on plasma coagulation inhibitors. . J Thromb Haemost. 2020; 18: 17– 22.
- Recommendations for clinical laboratory testing of activated protein C resistance; communication from the SSC of the ISTH
Moore, G. W., Van Cott, E. M., Cutler, J. A., Mitchell, M. J., Adcock, D. M. and , (2019), Recommendations for clinical laboratory testing of activated protein C resistance; communication from the SSC of the ISTH. J Thromb Haemost, 17: 1555-1561.